CALDERWOOD DAVID J.,BREINLINGER ERIC C.,SWANN STEVEN L.,MUKHERJEE SUBHENDU,CHITTY VENKATA SRIKANTH,THUNUGUNTLA SIVA SANJEEVA RAO,HOSAHALLI SUBRAMANYAH SEETHARAMA SHASTRY
申请号：
ARP120101453
公开号：
AR086113A1
申请日:
2012.04.26
申请国别(地区):
AR
年份:
2013
代理人:
摘要：
The compounds of the present are useful to treat immunological conditions.Claim 1: wherein is a compound of formula (1), Biologically Active metabolites, prodrugs, isomers, stereoisomers, pharmaceutically acceptable Salts and solvates, hydrates of the same, which is selected from the group of formulas (2)； X is a Ring System OPC Ionalmente substituted AromaticPartially Aromatic or non Aromatic systems with one or more Rings and is optionally substituted heteroaryl FUSED；； Z is nrcrd, - C (o) - C (o) - OCH3, nrcrd alkyl, optionally substituted cycloalkyl C1 - C3 - 6, 6 optionally substituted, optionally substituted aryl, heteroaryl option At present, replaced or optionally substituted heterocycle； ra is independently h,C1-3 alkyl or cycloalkyl, optionally substituted C3 6 optionally substituted； RB is independently h, CF3, c1-3 alkyl or cycloalkyl, optionally substituted C3 6 optionally substituted； RC and Rd is H is H or alkyl, optionally substituted C1 - 6； or RC and Rd, along with the N Atom Itr u00f3geno which are United to form a saturated or unsaturated Heterocyclic Ring System.Aromatic or non Aromatic 5 or 6 members； r1 is independently h, prays, BR, CL, F, c1-3 alkyl or cycloalkyl, optionally substituted C3 6 optionally substituted； RZ is H, alkyl or cycloalkyl, optionally substituted 3 C1 - C3 - 6 optionally substituted； M is 0, 1 or 2； n is 0, 1, 2 or 3； and P is 0, 1, 2 or 3； with the condition that when and pyridinyl,Is not replaced with phenyl optionally substituted.Los compuestos de la presente son útiles para tratar condiciones inmunológicas.Reivindicación 1: Un compuesto caracterizado porque es de fórmula (1), metabolitos biológicamente activos, prodrogas, isómeros, estereoisómeros, solvatos, hidratos y sales farmacéuticamente aceptables del mismo, donde A es seleccionado del grupo de formulas (2)； X es un sistema de anillos opcionalmente sustituido que es aromático, parcialmente aromático o no aromático con uno o más sistemas de anillos fusionados； Y
