An ameliorating agent for chronic obstructive pulmonarydisease (COPD) containing as an active ingredient a lecithinizedsuperoxide dismutase represented by the following general formula(I):SOD'(Q-B)m (I)(in the formula SOD' represents a residue of the superoxidedismutase； Q represents a chemical crosslinking； B represents aresidue without a hydrogen atom of a hydroxyl group of lysolecithinhaving the hydroxyl group at the 2-position of glycerol； m is theaverage number of bonds of lysolecithin to one molecule of superoxidedismutase and represents an integer of 1 or more). The amelioratingagent for COPD is intravenously administered or inhalation-administrated.
