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Water-soluble taxane derivatives and uses thereof
专利权人:
发明人:
Qingeng Li,Tao Wang,Gang Chen,Yuanzhong Wang,Wei Mao,Lingguo Zeng,Tong Wu,Dahai Chen
申请号:
US15119603
公开号:
US09650390B2
申请日:
2015.02.16
申请国别(地区):
US
年份:
2017
代理人:
摘要:
The present invention discloses a class of water soluble taxane derivatives, a method for treating tumor using the same, use thereof as anti-tumor drugs and use thereof in the preparation of anti-tumor drugs. The water soluble taxane derivatives have the general formula (I-1), (I-2) or (I-3): wherein, R1 is H or methyl R2 is H, methyl or acetyl R3 is phenyl or OC(CH3)3 X is H, C1-6 alkyl or F Y is F or C1-6 alkyl substituted with one or more F n is 1, 2, 3, 4, 5 or 6 W is NR4R5.A orR4 and R5 are each independently H, C1-6 alkyl optionally substituted with phenyl, or C3-6 cycloalkyl m is 0, 1, 2 or 3 and A is a pharmaceutically acceptable acid.
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