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PROCÉDÉ D'EXTRACTION DE CANNABINOÏDES À PARTIR D'UNE MATIÈRE VÉGÉTALE DE CANNABIS
专利权人:
AALBORG UNIVERSITET
发明人:
VOROBJOV, Filip,SØGAARD, Erik, Gydesen
申请号:
EPEP2018/056201
公开号:
WO2018/167038A1
申请日:
2018.03.13
申请国别(地区):
EP
年份:
2018
代理人:
摘要:
The present invention relates to a method for extracting cannabinoids from cannabis plant material using an extractor with super critical carbon dioxide. The process comprises the steps of: a) providing a cannabis plant material with a water content of at most 60% w/w, preferably at most 10% w/w; b1) in a pressure tank, subjecting the cannabis plant material to a first extraction step with a one-phase solvent system comprising supercritical carbon dioxide and optionally a non-polar co-solvent, and performed at a temperature of about 30-60 degrees Celsius; c1) collecting a first liquid extract from the pressure tank; d) collecting/removing a solid product from the pressure tank comprising a cannabis plant fiber material with a reduced content of cannabinoids; e) dissolving the first liquid extract from the pressure tank in ethanol, subjecting the solution to one or more winterization steps, filtrating the solution to remove precipitated matter, and removing the ethanol to collect a second liquid extract; f) optionally, heat treating the second liquid extract at 100-150 degrees Celsius to decarboxylate any acid form of the cannabinoids to the neutral form of the cannabinoids; g) dissolving the second liquid extract, optionally heat treated, in a non-polar solvent; h) extracting the solubilized second liquid extract with an aqueous basic solution; and collecting the non-polar solvent phase as a third liquid extract; and i) optionally, removing the non-polar solvent to collect the neutral form of the cannabinoids.La présente invention concerne un procédé d'extraction de cannabinoïdes à partir d'une matière végétale de cannabis à l'aide d'un extracteur à dioxyde de carbone supercritique. Le procédé comprend les étapes consistant à : a) utiliser une matière végétale de cannabis ayant une teneur en eau inférieure ou égale à 60 % p/p, de préférence inférieure ou égale à 10 % p/p ; b1) dans un réservoir sous pression, soumettre la matière végétale de cannabis à une première
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