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Enantiomers of the 1 ', 6'-isomer of neplanocin A
专利权人:
オーバーン・ユニバーシティ
发明人:
シュネッラー,スチュワート ダブリュ.,リウ,チョン,チェン,チー,イェ,ウェイ
申请号:
JP2017506930
公开号:
JP6546268B2
申请日:
2015.08.04
申请国别(地区):
JP
年份:
2019
代理人:
摘要:
Enantiomers of 1′,6′-isoneplanocin, including derivatives of the enantiomers of 1′,6′-isoneplanocin, are disclosed along with novel synthetic methods. In particular, a substituted cyclopentane epoxide is synthesized into the enantiomers of 1′,6′-isoneplanocin. Enantiomers of carbocyclic nucleoside analogs of 3-deazaneplanocin to provide D- and L-like 1′,6′-iso-3-deazaneplanocin are also disclosed. The small molecule chemotherapeutic compounds beneficially provide DNA and RNA antiviral activity, demonstrating activity towards, for example, human cytomegalovirus, measles, Ebola, norovirus, dengue, vaccinia and HBV. Compounds exhibiting reduced S-adenosylhomocysteine hydrolase inhibitory effects are disclosed and provide improved toxicity profiles in comparison to neplanocin. The invention provides improved prophylactic and/or therapeutic antiviral efficacy.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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