A syringe adapter includes a housing defining an interior space, a seal arrangement including a membrane received within the interior space of the housing with the seal arrangement moveable within the housing, a connector body positioned adjacent to a first end of the housing and configured to be connected with a syringe barrel. The connector body including a locking projection that cooperates with the retaining ring of the housing to secure the connector body to the housing. The connector body is rotatable relative to the housing in first and second directions. The locking projection engages the retaining ring to restrict axial movement of the connector body relative to the housing. The syringe adapter also includes a cannula secured to the connector body with the seal arrangement configured to cooperate with the cannula to provide a sealed transfer of fluids through the cannula to a mating connector.
