A topical composition which is suitable for treating or preventing skin or mucosal infectious disorders or troubles in humans, in particular for treating or preventing urinary tract infections and lower vaginal tract infections in females comprises an oily primary phase and a complementary aqueous phase wherein the oily primary phase consists of a non polar mineral or silicone comprising an efficient amount of at least one viable probiotic bacteria strain, in particular a lactobacillus strain. The composition is also useful for suitable for balancing or restoring skin or mucosal indigenous microflora in humans, in particular for balancing or restoring the local urinary tract and lower vaginal tract bacterial flora in females.