DEWDNEY, NOLAN JAMES,KENNEDY-SMITH, JOSHUA -,KONDRU, RAMA K. K,LOE, BRADLEY E. E,LOU, YAN,MCINTOSH, JOEL,OWENS, TIMOTHY D. D,SOTH, MICHAEL,SWEENEY, ZACHARY KEVIN,TAYGERLY, JOSHUA PAUL GERGELY,邁克爾‧索思,扎,諾蘭‧詹姆斯‧德沃丹尼,喬舒亞‧肯尼迪-史密斯,拉馬‧,‧孔杜,布拉德利‧,‧洛伊,婁岩,喬爾‧麥金托什,SWEENEY,
申请号：
HK11100915.9
公开号：
HK1146826B
申请日:
2011.01.28
申请国别(地区):
HK
年份:
2014
代理人:
摘要：
This application discloses 5-phenyl-1H-pyridin-2-one and 6-phenyl-2H-pyridazin-3-one deriva-tives according to generic Formulae I-III : wherein, variables R, X, Y1, Y2, Y3, Y4, n and m are defined as described herein, which inhibit Btk. The compounds disclosed herein are useful to modulate the activity of Btk and treat diseases associated with excessive Btk activity. The compounds are further useful to treat in-flammatory and auto immune diseases associated with aberrant B-cell proliferation such as rheumatoid arthritis. Also disclosed are compositions containing compounds of Formulae I-III and at least one carrier, diluent or excipient.
