INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE);INSTITUT JEAN PAOLI &； IRENE CALMETTES;UNIVERSITE D'AIX-MARSEILLE;Universite Claude Bernard—；Lyon 1;Centre Leon Berard
The present invention provides antibodies directed against ICOS or a derivative thereof which neutralize ICOS engagement on Treg by inhibiting the fixation between ICOS and ICOS-L and abrogate proliferation of Treg induced by plasmacytoid dendritic cells. The present invention further provides antibodies directed against ICOS or a derivative thereof which induce IL-10 and IFNγ production, induce CD4−； T cells proliferation, reduce Tconv proliferation, and increase the immunosuppressive function of Treg.
