Inhibitors of receptor tyrosine kinases and methods of use thereof

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专利权人:

Yale University

发明人:

Lax, Irit,Schlessinger, Joseph,Opatowsky, Yarden,Yang, Yan,Yuzawa, Satoru

申请号：

AU2014203645

公开号：

AU2014203645A1

申请日:

2014.07.03

申请国别(地区):

AU

年份:

2014

代理人:

摘要：

#$%^&*AU2014203645A120140724.pdf#####INHIBITORS OF RECEPTOR TYROSINE KINASES AND METHODS OF USE THEREOF 5 ABSTRACT The present invention provides moieties that bind to an Ig-like domain, e.g., D4 or D5, of a human receptor tyrosine kinase, e.g., the human Kit RTK or the PDGFR RTK, or the D7 domain of a type V receptor tyrosine kinase wherein the moieties lock 10 the ectodomain of the receptor tyrosine kinase in an inactive state thereby antagonizing the activity of the receptor tyrosine kinase. 191

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