The invention provides combinations comprising a MEK inhibitor (such as GDC-0973 or GDC-0623), or a pharmaceutical ly acceptable salt thereof and an ERK inhibitor (such as GDC-0994). The combinations are particularly useful for treating hyperproliferative disorders, such as cancer.本發明提供包括MEK抑制劑(例如GDC-0973或GDC-0623)或其醫藥上可接受之鹽及ERK抑制劑(例如GDC-0994)之組合。該等組合尤其可用於治療諸如癌症等過度增生病症。