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Liquid nasal spray containing low-dose naltrexone
- 专利权人:
- L. MOLTENI & C. DEI FRATELLI ALITTI SOCIETA’ DI ESERCIZIO S.p.A.
- 发明人:
- Angeli Roberto,Raffaeli William,Rigamonti Maria Adele
- 申请号：
- NZ60441711
- 公开号：
- NZ604417A
- 申请日:
- 2011.05.20
- 申请国别(地区):
- NZ
- 年份:
- 2014
- 代理人:
- 摘要：
- ABSTRACT - 604417 The disclosure relates to a spray formulation for administration of opioid antagonists at low concentrations by the nasal route for reducing the adverse side-effects of opioids such as morphine, particularly in oncologic patients receiving therapy, wherein the formulation comprises one of the following compositions: (1) Hydroxypropyl methylcellulose 0.2%w/v Benzalkonium chloride 0.02%w/v Anhydrous citric acid 0.14%w/v Sodium citrate dihydrate 0.37%w/v Sodium chloride 0.72% w/v Naltrexone hydrochloride 0.010%w/v； (2) Hydroxypropyl methylcellulose 0.2%w/v Sodium propyl parahydroxybenzoate 0.02%w/v Anhydrous citric acid 0.14%w/v Sodium citrate dihydrate 0.37%w/v Sodium chloride 0.72% w/v Naltrexone hydrochloride 0.010%w/v； or (3) Methylcellulose 0.5%w/v Benzalkonium chloride 0.02%w/v Anhydrous citric acid 0.14%w/v Sodium citrate dihydrate 0.37%w/v Sodium chloride 0.72% w/v Naltrexone hydrochloride 0.010%w/v
- 来源网站：
- 中国工程科技知识中心
- 来源网址：
- http://www.ckcest.cn/home/
