Liquid nasal spray containing low-dose naltrexone

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专利权人:

L. MOLTENI & C. DEI FRATELLI ALITTI SOCIETA’ DI ESERCIZIO S.p.A.

发明人:

Angeli Roberto,Raffaeli William,Rigamonti Maria Adele

申请号：

NZ60441711

公开号：

NZ604417A

申请日:

2011.05.20

申请国别(地区):

NZ

年份:

2014

代理人:

摘要：

ABSTRACT - 604417 The disclosure relates to a spray formulation for administration of opioid antagonists at low concentrations by the nasal route for reducing the adverse side-effects of opioids such as morphine, particularly in oncologic patients receiving therapy, wherein the formulation comprises one of the following compositions: (1) Hydroxypropyl methylcellulose 0.2%w/v Benzalkonium chloride 0.02%w/v Anhydrous citric acid 0.14%w/v Sodium citrate dihydrate 0.37%w/v Sodium chloride 0.72% w/v Naltrexone hydrochloride 0.010%w/v； (2) Hydroxypropyl methylcellulose 0.2%w/v Sodium propyl parahydroxybenzoate 0.02%w/v Anhydrous citric acid 0.14%w/v Sodium citrate dihydrate 0.37%w/v Sodium chloride 0.72% w/v Naltrexone hydrochloride 0.010%w/v； or (3) Methylcellulose 0.5%w/v Benzalkonium chloride 0.02%w/v Anhydrous citric acid 0.14%w/v Sodium citrate dihydrate 0.37%w/v Sodium chloride 0.72% w/v Naltrexone hydrochloride 0.010%w/v

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