The present invention relates to methylene-tetrahydrofolate for use in cancer therapy based on its inherent anti-tumor activity. Cancers that can be treated include breast cancer, stomach cancer, gastrointestinal cancer, gallbladder cancer, bile duct cancer, colon cancer, rectal cancer, liver cancer, pancreas cancer, head and neck cancer, esophageal cancer, medium Skin cancer, lung cancer including non-small cell lung cancer, ovarian cancer, endometrial cancer, cervical cancer, peripheral T-cell lymphoma (PTCL), melanoma, brain tumor, adenocarcinoma, esophageal cancer and bone Sarcomas are included.本発明は、その固有の抗腫瘍活性に基づくがん治療における使用のためのメチレン－テトラヒドロフォレートに関する。治療され得るがんには、乳がん、胃がん、胃腸がん、胆嚢がん、胆管がん、結腸がん、直腸がん、肝臓がん、膵臓がん、頭頸部がん、食道がん、中皮腫がん、非小細胞肺がんを含めた肺がん、卵巣がん、子宮内膜がん、子宮頸がん、末梢Ｔ細胞リンパ腫（ＰＴＣＬ）、黒色腫、脳腫瘍、腺癌、食道がんおよび骨肉腫が含まれる。
