A pressure sensor and method of use provides for the detection of a sudden increase or decrease of pressure within tubing during the administration of solutions to a patient. Detection of an occlusion, partial occlusion or other significant pressure change in the tubing is accomplished by measuring the compression and/or expansion of the tubing. Transfer of the change in force within the tubing is communicated from the tubing to a sensor by a transfer rod which as a membrane attached thereto to provide a seal thereabout.