ILLIG, Carl R.,CHEN, Jinsheng,MEEGALLA, Sanath K.,WALL, Mark J.
申请号：
ES08839490
公开号：
ES2614754T3
申请日:
2008.10.16
申请国别(地区):
ES
年份:
2017
代理人:
摘要：
Compound of Formula I: ** Formula ** or pharmaceutically acceptable solvate, hydrate, tautomer or salt thereof, wherein: ** Formula ** W is in which each R4 is independently H, F, Cl, Br, I , OH, OCH3, OCH2CH3, Salkyl C (1-4), SOalkyl C (1-4), SO2alkyl C (1-4), -alkyl C (1-3), CO2Rd, CONReRf, ≡CRg or CN； in which Rd is H or -alkyl C (1-3)； Re is H or - C (1-3) alkyl； Rf is H or - C (1-3) alkyl； and Rg is H, -CH2OH or -CH2CH2OH； R2 is cycloalkyl, spiro-substituted cycloalkenyl, thiophenyl, dihydrosulfonopyranyl, phenyl, furanyl, tetrahydropyridyl or dihydropyranyl, any of which may be independently substituted with one or two of each of the following: chlorine, fluoro, hydroxy, C (1) alkyl -3), and C (1-4) alkyl； Z is H, F, Cl or CH3； J is CH or N； X is ** Formula ** in which Rw is H, -C (1-4) alkyl, -CO2C (1-4) alkyl, -CONH2, -CONC (1-4) alkyl, -CON (C (alkyl) 1-4)) 2, or -Calkyl C (1-4).Compuesto de Fórmula I:**Fórmula** o solvato, hidrato, tautómero o sal farmacéuticamente aceptable del mismo, en el que:**Fórmula** W es en el que cada R4 es independientemente H, F, Cl, Br, I, OH, OCH3, OCH2CH3, Salquilo C(1-4), SOalquilo C(1-4), SO2alquilo C(1-4), -alquilo C(1-3), CO2Rd, CONReRf, ≡CRg o CN； en el que Rd es H o -alquilo C(1-3)； Re es H o -alquilo C(1-3)； Rf es H o -alquilo C(1-3)； y Rg es H, -CH2OH o -CH2CH2OH； R2 es cicloalquilo, cicloalquenilo espiro-sustituido, tiofenilo, dihidrosulfonopiranilo, fenilo, furanilo, tetrahidropiridilo o dihidropiranilo, cualquiera de los cuales puede estar independientemente sustituido con uno o dos de cada uno de los siguientes: cloro, fluoro, hidroxi, alquilo C(1-3), y alquilo C(1-4)； Z es H, F, Cl o CH3； J es CH o N； X es**Fórmula** en el que Rw es H, -alquilo C(1-4), -CO2alquilo C(1-4), -CONH2, -CONHalquilo C(1-4), -CON(alquilo C(1-4))2, o -COalquilo C(1-4).
