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A process for the preparation of ralfinamide-methanesulphonate or R-enantiomers thereof.
专利权人:
Newron Pharmaceuticals S.p.A.
发明人:
GIORDANO, Claudio,WALDVOGEL, Erwin
申请号:
DK11714958
公开号:
DK2563355T3
申请日:
2011.04.06
申请国别(地区):
DK
年份:
2016
代理人:
摘要:
The invention relates to a new process for the production and/or purification of the salt of the compound (S)-2-[4-(2-fluorobenzyloxy) benzylamino]propanamide, i.e. ralfinamide, or the respective R-enantiomer, with methane sulfonic acid in high yields and very high enantiomeric and chemical purity in the form of the crystalline anhydrous polymorph identified as form A, wherein said salt is substantially free from impurities having genotoxic effect, such as (C1-C5)alkanylmethanesulfonates, and residual solvents known as potential precursors thereof, such as (C1-C5)alkanols or esters thereof with lower alkanoic acids.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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