An electrical simulation system and a method of the multi-group electrode array are disclosed in the present invention. The system comprises an implanted carrier, an electrode array, and an electrode controller. The implanted carrier has an overload surface, and the overload surface is disposed the electrode array. The electrode array comprises a plurality of electrode groups. The electrode group comprises a plurality of electrodes. Each of the electrodes is provided with an independent controlled power source. The electrode controller receives a control signal and accordingly at least two corresponding electrodes are drived with independently controlled power source, thereby a virtual channel is generated between the at least two electrodes due to the electric interaction therebetween.本發明係揭露一種多群組電極陣列的電極刺激系統及其方法,多群組電極陣列的電極刺激系統包含植入本體、電極陣列及電極控制器。植入本體具有承載面,承載面設置有電極陣列。電極陣列具有多個電極群組,電極群組具有多個電極,電極分別具有獨立的電源控制。電極控制器接收控制訊號以驅動對應電極,對應電極包含至少兩個電極,並透過獨立的電源控制調整供給對應電極電源,經由電交互作用使產生介於對應電極間的虛擬頻道。