Silica-based biomolecule carriers, compositions comprising the same and preparation methods and uses thereof for delivering biomolecules into a cell are provided. The silica-based biomolecule carrier comprises a porous core a first bioactive moiety a second bioactive moiety functionally associated with the first bioactive moiety and linkers for respectively conjugating the first bioactive moiety and the second bioactive moiety to the porous core.本發明提供一種氧化矽型生物分子載體、包含其之組成物及其製備方法與用於遞送生物分子至細胞中的用途。該氧化矽型生物分子載體包含一多孔性核;一第一生物活性部分;與該第一生物活性部分功能上相關聯的一第二生物活性部分;以及用於將該第一生物活性部分與第二生物活性部分分別接合至該多孔性核的連接子。
