The present invention provides a compound represented by the following formula (I): wherein each symbol is as described in the DESCRIPTION, which has a superior peripheral blood lymphocyte decreasing action, and is useful for the treatment or prophylaxis of autoimmune diseases； prophylaxis or suppression of resistance or acute rejection or chronic rejection of transplantation of organ or tissue； treatment or prophylaxis of graft-versus-host (GvH) disease due to bone marrow transplantation； or treatment or prophylaxis of allergic diseases.
