A syringe adapter element (200) for use in a drug mixing system including a housing element (500) having a syringe port adapted for fluid connection with a syringe and a fluid port (202) adapted for fluid connection with a fluid flow adapter element (204), a needle (550) and at least one septum (502, 504) disposed in the housing element (500), the needle (550) having a sealed orientation wherein the at least one septum (502, 504) blocks fluid flow through the needle (550) and a fluid flow orientation wherein the needle (550) punctures the at least one septum (502,504) so as to permit fluid to flow through the needle, and an anti-separation device (206) adjacent the fluid port, such that when the syringe adapter element (200) is connected to the fluid flow adapter element (204), the anti-separation (206) device applies a force that acts against separating the syringe adapter element (200) from the fluid flow adapter element (204).
