Salts and hydrates of 4-[(3-chloro-4-fluoro-phenyl)amino]-6-(cis-4--cyclohexan-1-yloxy)-7-methoxy-quinazoline, their use as a medicament and the preparation thereof
Werner RALL;Rainer SOYKA;Peter SIEGER;Marco SANTAGOSTINO;Juergen SCHNAUBELT;Marc EGEN
发明人:
Marc EGEN,Werner RALL,Marco SANTAGOSTINO,Juergen SCHNAUBELT,Peter SIEGER,Rainer SOYKA
申请号：
US13026817
公开号：
US20120046284A1
申请日:
2011.02.14
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The present invention relates to a compound of formula (I),wherein x Q denotes x H2O x HCl； or x 0.5 HCl x 1.5 H2O,which have valuable pharmacological properties, particularly an inhibitory effect on signal transduction mediated by tyrosine kinases, processes for the stereoselective preparation of this compound, particularly for the inhalation of suitable pharmaceutical formulations and their use for the treatment of diseases, particularly tumour diseases, benign prostatic hyperplasia and diseases of the lungs and airways.
