FIELD: medicine, pharmaceutics.SUBSTANCE: group of inventions relates to medicine and describes a composition of digestive enzymes which contains granules covered with an enterosoluble coating, which contain a digestive enzyme, and digestive enzyme-containing granules, which are not covered with a coating, where the granules covered with the enterosoluble coating, which contain the digestive enzyme, contain a core and the enterosoluble coating, located on the core, where the core contains a therapeutically effective quantity of lipase, and the enterosoluble coating contains an enterosoluble polymer； and the digestive enzyme-containing granules, which are not covered with a coating, contain a therapeutically effective quantity of protease and in fact do not contain the enterosoluble polymer coating； where the lipase activity of the coating-covered granules is in the range from approximately 1000 USP units to approximately 10000 USP units, and protease activity in the granules which are not covered with the coating is in the range from approximately 65000 USP units to approximately 34000 USP units. Also methods of treating pain in case of pancreatitis and pancreas insufficiency, as well as a method for the treatment of exocrine insufficiency of the pancreas are described.EFFECT: group of inventions makes it possible to achieve an effective and safe clinical result in a low dose.16 cl, 20 tbl, 10 exГруппа изобретений относится к медицине и описывает композицию пищеварительных ферментов из множества частиц для лечения недостаточности поджелудочной железы и боли при панкреатите, содержащую покрытые энтеросолюбильной оболочкой гранулы, содержащие пищеварительный фермент, и непокрытые оболочкой гранулы, содержащие пищеварительный фермент, где: покрытые энтеросолюбильной оболочкой гранулы, содержащие пищеварительный фермент, содержат ядро и энтеросолюбильную оболочку, расположенную на ядре, где ядро содержит терапевтически эффективное количество липазы, и энтеросолюбильная
