A novel therapeutic agent for organ disease, in particular, a therapeutic agent for liver disease is provided. It has been found that a diarylsulfide or diarylether derivative having 2-amino-1,3-propanediol structure, the compound that act as a sphingosine-1-phosphate receptor agonist, and a pharmaceutically acceptable salt and hydrate thereof are used as effective therapeutic agents for various diseases in organs, in particular liver diseases. The diarylsulfide or diarylether derivative is represented by the following general formula (1):본 발명은 신규 장기질환 치료제, 특히 간장질환 치료제를 제공한다.일반식(1)[화학식 1]로 표시되는 스핑고신-1-인산수용체 아고니스트인 2-아미노-1,3-프로판디올 구조를 가지는 디아릴설파이드 또는 디아릴에테르 유도체 및 약학적으로 허용되는 그 염 및 수화물은 장기질환 치료제, 특히 간장질환 치료제로서 유용한 것을 발견하였다.
