Use of car and bite technology coupled with an scFv from an antibody against human thymidine kinase 1 to specifically target tumors

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专利权人:

Kim Leslie O'Neill;Scott Weber

发明人:

Kim Leslie O'Neill,Scott Weber

申请号：

US15161045

公开号：

US10434153B1

申请日:

2016.05.20

申请国别(地区):

US

年份:

2019

代理人:

摘要：

Modified T-cells have paratopes against human TK1 epitopes, are made by producing monoclonal antibodies that are specific to TK1, creating chimeric antigen receptors (CARs) by fusion of the single-chain variable fragments (scFv) of the monoclonal antibodies to T-cell signalling domains, and transducing the CARs to the T-cells.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/