The Board of Trustees of the Leland Stanford Junior University
发明人:
Shamloo, Mehrdad,Jahangir, Alam,Yi, Bitna,Evans, Andrew Kelley,Green, Michael John
申请号：
AU2017263657
公开号：
AU2017263657A1
申请日:
2017.05.12
申请国别(地区):
AU
年份:
2018
代理人:
摘要：
Adrenergic receptor modulating compounds and methods of using the same are provided. Also provided are methods of treating a subject for a disease or condition associated with an adrenergic receptor including administering a therapeutically effective amount of the subject compound. Aspects of the disclosure include a method of modulating an inflammatory pathway in a cell, such as the production of TNF-alpha in the cell. The method can include contacting a cell with a β1-selective adrenergic receptor modulating compound to selectively activate a cAMP pathway over a beta-arrestin pathway in the cell. Pharmaceutical compositions and kits which include the subject compounds are provided.
