2-(PYRAZIN-2-YL)-THIAZOLE AND 2-(1H PYRAZOL-3-YL)-THIAZOLE DERIVATIVES AS WELL AS RELATED COMPOUNDS AS STEAROYL-COA DESATURASE (SCD) INHIBITORS FOR THE TREATMENT OF METABOLIC, CARDIOVASCULAR AND OTHER DISORDERS
The present invention relates generally to the field of inhibitors of stearoyl-CoA desaturase, such as heterocyclic derivatives, and uses for such compounds in treating and/or preventing various human diseases, including ihose mediated by stearoyl-CoA desaturase (SCD) enzymes, preferably SCDl, especially diseases related to elevated lipid levels, cardiovascular disease, diabetes, obesity, metabolic syndrome, dermatological disorders and the like. The invention provides compounds of formula (I): X is N or CH Y is NH, O, S or N-CH3 Q is formulae (a), (b), ou (c).La présente invention concerne des dérivés hétérocycliques qui modulent lactivité de la stéaroyl-CoA désaturase. Linvention concerne également des procédés dutilisation de tels dérivés pour moduler lactivité de la stéaroyl-CoA désaturase et des compositions pharmaceutiques comprenant de tels dérivés.
