The invention provides a human antibody that is specific for CD38. The antibody of the invention has the ability to bind to CD38 of minipig origin and induce, by cross-linking, specific killing of cells, in particular tumor cells, expressing CD38. The invention further provides uses of this antibody for treating various disorders and conditions associated with undesired presence of CD38+ cells, including hematological and inflammatory diseases. The invention also provides diagnostic compositions and methods based on detecting the presence of CD38 in a tissue or a cell of minipig origin contacted with the antibody of the invention.本發明提供新穎抗體及使用重組抗原結合區以及包含該等對CD38有特異性之抗原結合區之抗體及功能片段的方法，其中CD38在多種病症或病況中扮演重要角色。此等方法有利於新發現之抗體及此等抗體令人驚奇之性質，例如結合小種豬來源之CD38之能力及藉由交聯誘發特異性殺死表現CD38細胞之能力。此等抗體以及使用該等抗體之新穎方法可用於治療(例如)血液惡性腫瘤，例如多發性骨髓瘤。
