Zalfa A. ABDEL-MALEK,Leonid KOIKOV,James J. KNITTEL
申请号：
MX2015006333
公开号：
MX366171B
申请日:
2013.11.20
申请国别(地区):
MX
年份:
2019
代理人:
摘要：
Short tri- and tetrapeptides according to the following Formula I Ar(CH2)mX1-X2-CO-X3 -X4-X5-(Trp) n -NX6R are potent, selective agonists of melanocortin 1 receptor (MC1R). Provided herein are pharmaceutical compositions including Formula I peptide agonists of MC1R and methods of treating skin diseases and disorders that include administering to an individual in need thereof a therapeutic amount of a Formula I peptide. The peptides, pharmaceutical compositions, and methods described herein are useful in the treatment of diseases and disorders that benefit from agonism of MCIR, including melanoma, basal cell carcinoma, squamous cell carcinoma, porphyria, polymorphous light eruption, vitiligo, and solar urticaria.La presente invención se refiere a los tri- y tetrapéptidos cortos de acuerdo con la siguiente Fórmula I Ar (CH2) mX1-X2-CO-X3-X4-X5-(Trp) n-NX6R son agonistas, selectivos, potentes del receptor de melanocortina 1 (MC1R). Se proporcionan en la presente composiciones farmacéuticas que incluyen los agonistas de péptido de la Fórmula I de MC1R y métodos para tratar enfermedades de la piel.
