An endoscopic system which can provide guidance enabling acquisition of an index value that cannot be acquired under current imaging conditions, and an operation method of said endoscopic system are provided. This endoscopic system is provided with an imaging condition acquisition unit, an index value and imaging condition storage unit, an imaging condition extraction unit, and a guidance display unit. The imaging condition acquisition unit acquires a first imaging condition as the imaging condition under which the observation target is observed with an endoscope. The index value and imaging condition storage unit stores correspondence relations between imaging conditions and index values which, as index values relating to the structure of the observation target, include a first index value that can be acquired under a first imaging condition, and a second index value that cannot be acquired under the first imaging condition but that can be acquired under a second imaging condition. The imaging condition extraction unit refers to the index value and imaging condition storage unit and extracts a second imaging condition. The guidance display unit displays guidance indicating that the second index value can be acquired under the extracted second imaging condition.L'invention concerne un système d'endoscopie qui peut fournir une indication permettant l'acquisition d'une valeur d'indice qui ne peut pas être acquise dans les conditions d'imagerie en cours, et un procédé de fonctionnement dudit système d'endoscopie. Ce système d'endoscopie est pourvu d'une unité d'acquisition de conditions d'imagerie, d'une unité de stockage de valeurs d'indice et de conditions d'imagerie, d'une unité d'extraction de conditions d'imagerie et d'une unité d'affichage d'indications. L'unité d'acquisition de conditions d'imagerie acquiert une première condition d'imagerie qui correspond à la condition d'imagerie dans laquelle la cible d'observation est observée à l'aide d'un endoscope. L'unit