Antagonist anti-Notch3 antibodies and their use in the prevention and treatment of Notch3-related diseases

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专利权人:

Inc.;Genentech

发明人:

Sek Chung Fung,Kang Li,Zhengbin Yao

申请号：

US13669230

公开号：

US09873734B2

申请日:

2012.11.05

申请国别(地区):

US

年份:

2018

代理人:

摘要：

The present invention relates to antagonist antibodies that specifically bind to Notch 3 and inhibit its activation. The present invention includes antibodies binding to a conformational epitope comprising the first Lin12 domain and the second dimerization domain. The present invention also includes uses of these antibodies to treat or prevent Notch 3 related diseases or disorders.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/