The present invention relates to a recombinant poxvirus vector capable ofexpressing two or more homologous, foreign sequences, which derive fromdifferent variants of a microorganism, and which have a homology of 50% orabove. The invention further relates to a method for preparing suchrecombinant poxvirus and the use of such recombinant poxvirus as medicament orvaccine. Additionally, a method for affecting preferably inducing , an immuneresponse in a living animal, including a human, is provided.