Disclosed herein is a biological nerve guide for implantation in to a humanbody, having goodbiocompatibility, along with safe/reliable application thereof, and a methodof preparation thereof. Thebiological nerve guide is made by providing a natural animal tissue membrane,crosslinking and fixingthe membrane, minimizing the antigens from the membrane, tanning the membrane,coupling an activelayer to an inner surface of the membrane, cutting the membrane into a desiredshape and size,positioning the cut membrane onto a rod-shaped mould so that the cut membraneassumes a cylindricalconfiguration, and attaching a spiral support to the outer surface of the cutmembrane.
