KIMS HEALTHCARE CO., LTD.;INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY
发明人:
Seung Hyun KIM,Sung Joo HWANG,Jun Hyun AHN,Sang Min HYUN,Sang Won KWAK,Bo Kyung SUN,Seung Hyeon HONG,Ye Ji SEO
申请号：
US16500311
公开号：
US20200323780A1
申请日:
2018.04.03
申请国别(地区):
US
年份:
2020
代理人:
摘要：
A bilayer combination tablet for oral administration, which is prescribed for alleviation of symptoms or signs of osteoarthritis (degenerative arthritis), alleviation of symptoms or sings of rheumatoid arthritis, alleviation of symptoms or signs of ankylosing spondylitis, alleviation of acute pain in adults (post-operative or post-tooth extraction pain), alleviation of primary dysmenorrhea, or alleviation of severe and moderate acute or chronic pain. The bilayer combination tablet includes: a controlled-release layer containing tramadol as an active ingredient； and an immediate-release layer containing celecoxib as an active ingredient. A composition for treating pain may be provided, which has a long-lasting analgesic effect for 12 hours while reducing the side effects of tramadol by slow release of water-soluble tramadol and immediate release of poorly soluble celecoxib. In addition, the two drugs may be formulated into a single dosage form, and thus the number of medications may be reduced, thereby improving the convenience of drug administration.
