Compounds derived from 3 - pyrimidin-4-yl - oxazolidin ONA - 2 - and its Salts, such as inhibitors of the Protein Mutant IDH； Pharmaceutical composition that is useful for the treatment of proliferative Disorders such as cancer.
QIAN ZHAO,YOUNG SHIN CHO,FAN YANG,JULIAN ROY LEVELL,BAKARY-BARRY TOURE,THOMAS CAFERRO,HUANGSHU LEI,FRANCOIS LENOIR,GANG LIU,MARK G. PALERMO,MICHAEL DAVID SHULTZ,TROY D. SMITH,ABRAN Q. COSTALES,KEITH B
申请号：
CL2014000746
公开号：
CL2014000746A1
申请日:
2014.03.26
申请国别(地区):
CL
年份:
2014
代理人:
摘要：
The invention is directed to a compound of formula (I) or a pharmaceutically acceptable salt thereof, wherein R1-R6 are defined herein. The invention is also directed to compositions containing a compound of formula (I) and to the use of such compounds in the inhibition of mutant IDH proteins having a neomorphic activity. The invention is further directed to the use of a compound of formula (I) in the treatment of diseases or disorders associated with such mutant IDH proteins including, but not limited to, cell-proliferation disorders, such as cancer.COMPUESTOS DERIVADOS DE 3-PIRIMIDIN-4-IL-OXAZOLIDIN-2-ONA, INHIBIDORES DE LAS PROTEINAS IDH MUTANTES； COMPOSICION FARMACEUTICA QUE LOS COMPRENDE, UTILES EN EL TRATAMIENTO DEL CANCER.
