Andrea Hlubek,Christian Biesgen,Hans Wolfgang Höffken
申请号:
US13512202
公开号:
US20120284877A1
申请日:
2010.11.26
申请国别(地区):
US
年份:
2012
代理人:
摘要:
The invention relates to chimeric endonucleases, comprising a endonuclease and a heterologous DNA binding domain comprising one or more Zn2C6 zinc fmgers, as well as methods of targeted integration, targeted deletion or targeted mutation of polynucleotides using chimeric endonucleases.