Non-human animal has mutation kynureninase gene

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专利权人:

리제너론 파마슈티칼스 인코포레이티드

发明人:

키랏소스 크리스토스,무지카 알렉산더 오.

申请号：

KR1020187026249

公开号：

KR1020180110107A

申请日:

2017.02.16

申请国别(地区):

KR

年份:

2018

代理人:

摘要：

Non-human animal, composition and application method, wherein the non-human animal includes saltant type L- cynruins hydrolase (or kynureninase) gene. The non-human animal can be described, in some embodiments,There is the endogenous kynureninase gene of genetic modification as in, the non-human animal is allowed to express kynurenin enzyme polypeptide, it includes an amino acid replacement, therefore leads to the polypeptide for eliminating the kynureninase epitope, is to be present in nearly 1 gp41. of film perimeter human immunodeficiency virusDetoxic seedling

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中国工程科技知识中心

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http://www.ckcest.cn/home/