A pharmaceutical composition comprising: (A) an androgen； (B) a cyclic enhancer of the type used in the compositions and methods claimed by U.S. Patent No. 5,023,252 to Hsieh； and (C) a thickening agent； including, for example, a composition in which the cyclic enhancer is a macrocyclic ester or a macrocyclic ketone； the use of the composition to treat a condition, for example, male hypogonadism, in a patient by applying the composition to the membrane of the patient； and a method for making the composition.
