OBSCHESTVO S OGRANICHENNOY OTVETSTVENNOSTJU "BIOPHARM-MEMORIEN"
发明人:
NENAYDENKO, VALENTIN GEORGIEVICH,TKACHENKO, SERGEY EVGENIEVICH,BACHURIN, SERGEY OLEGOVICH,KABAKOV, VLADIMIR EVGENIEVICH,ANOKHIN, KONSTANTIN VLADIMIROVICH
申请号：
EP11822202
公开号：
EP2626352A4
申请日:
2011.08.30
申请国别(地区):
EP
年份:
2014
代理人:
摘要：
The invention relates to a novel class of non-peptide heterocyclic low-molecular peptide mimetics of secretory amyloid precursor protein (sAPP mimetics) capable of acting effectively upon the processes of the formation, storage and regeneration of normal and pathological memory. The compounds can also be used for studying ( in vitro and in vivo ) biochemical signaling, neurotrophic and neuroprotective processes related to the secretory protein sAPP and for studying the mechanisms of the formation, storage and regeneration of memory. Specifically, the invention relates to (azaheterocyclyl)alkyl derivative amides of 2-(het)arylglycines of general formula (I) in which: n and m can have the values 0, 1, 2 and 3； the symbol (#) here and hereinafter signifies the possible presence of a chiral centre； R represents optionally substituted C 5 -C 10 aryl or a 5-7-membered hetaryl containing 1-3 heteroatoms selected from nitrogen, oxygen and sulphur and optionally condensed with a benzene ring； A1 and A2 independently represent an optionally substituted, 3-7-membered, saturated, partially saturated or aromatic azaheterocycle which contains from 1 to 3 atoms of nitrogen in the cycle and is optionally condensed with a benzene ring； or their pharmaceutically acceptable salts or alkyl esters in the form of individual optical isomers, or combinations thereof.
