The present disclosure relates to compounds of formulae II, III and IV where the substituents are as defined herein as inhibitors of Notch signalling pathway in treating and/or preventing cancers, wherein the Notch dependent cancer is selected from the group comprising T cell-Acute lymphoblastic leukemia (T-ALL), chronic myeloid leukemia (CML), chronic lymphocytic leukemia (CLL), Mantle cell lymphoma (MCL), breast cancer, pancreatic cancer, prostate cancer, melanoma, brain tumors, tumor angiogenesis, and colorectal cancer. An example is the compound is: 6-(4-tert-butylphenoxy)pyridin-3-amine.
