ЧОУ Кен (US),ДИБАС Мохаммед И. (US),ДОНЕЛЛО Джон Е. (US),ГАРСТ Майкл Е. (US),ДЖИЛ Дэниел В. (US),ВАНГ Лиминг (US)
申请号：
RU2013116541/04
公开号：
RU2013116541A
申请日:
2011.09.16
申请国别(地区):
RU
年份:
2014
代理人:
摘要：
1. The compound of formula I, its individual enantiomers, its individual diastereoisomers, its hydrates, its solvates, its crystalline forms, its individual isomers, its individual tautomers or its pharmaceutically acceptable salt, where R is H or C1-6alkyl； R is H or C1-6alkyl； R is H, C1-6alkyl, heterocycle or aryl； and R is C1-6 alkyl, heterocycle or aryl. 2. A compound according to claim 1 of formula II, characterized in that its individual diastereoisomers, its hydrates, its solvates, its crystalline forms, its individual isomers, its individual tautomers or its pharmaceutically acceptable salt, where R is H or C1-6alkyl； R is H or C1-6alkyl ； R is H, C 1-6 alkyl, heterocycle or aryl； and R is C1-6 alkyl, heterocycle or aryl. 3. The compound according to claim 1 of formula III, its individual enantiomers, its individual diastereoisomers, its hydrates, its solvates, its crystalline forms, its individual isomers, its individual tautomers or its pharmaceutically acceptable salt, where R is H or C1-6 alkyl； R is H or C1-6 alkyl ； R is H, C 1-6 alkyl, heterocycle or aryl； and R is C1-6 alkyl, heterocycle or aryl. 4. The compound according to claim 2, where R is C1-6alkyl, R is C1-6alkyl, R is H, and R is C1-6alkyl. The compound of claim 2, wherein R is methyl, R is methyl, R is H, and R is C1-6alkyl. The compound according to claim 2, selected from: iso-butyric acid 3 - [(S) -1- (1H-imidazol-4-yl) -ethyl] -2-methyl-benzyl ether； 2,2-dimethyl-propionic acid 3 - [(S) -1- (1H-imidazol-4-yl) -ethyl] -2-methyl-benzyl ester； acetic acid 3 - [(S) -1- (1H-imidazol-4-yl) - ethyl] -2-methyl-benzyl ether； benzoic acid 3 - [(S) -1- (1H-imidazol-4-yl) -ethyl] -2-methyl-benzyl ether； 3-methyl1. Соединение формулы I, его отдельные энантиомеры, его отдельные диастереоизомеры, его гидраты, его сольваты, его кристаллические формы, его отдельные изомеры, его отдельные таутомеры или его фармацевтически приемлемая соль,,где Rявляется Н или Салкилом；Rявляется Н или Салкилом；Rявляется Н,
