用於治療癌症的化合物及組成物农业专利-农业学术服务平台

发明人:: GAGNON, LYNE,盖格诺　莱尼,蓋格諾　萊尼,GROUIX, BRIGITTE,格鲁伊克斯　布莱杰特,格魯伊克斯　布萊傑特,GEERTS, LILIANNE,吉尔特斯　里莱尼,吉爾特斯　里萊尼,LAURIN, PIERRE,拉瑞琳　皮尔瑞,拉瑞琳　皮爾瑞,PENNEY, CHRISTOPHER,班尼　克里斯多佛,ZACHARIE, BOULOS,扎恰里　鲍鲁斯,扎恰里　鮑,盖格诺莱尼,蓋格諾萊尼,格鲁伊克斯布莱杰特,格魯伊克斯布萊傑特,吉尔特斯里莱尼,吉爾特斯里萊尼,拉瑞琳皮尔瑞,拉瑞琳皮爾瑞,班尼克里斯多佛,扎恰里鲍鲁斯,扎恰里鮑

摘要：: New uses for phenylketone carboxylate compounds and substituted aromatic compounds of Formula I, Formula I.1, Formula I.2, Formula IA, Formula IB, Formula IC and Formula II and their pharmaceutical acceptable salts for the treatment of cancer. The use of a combination of two of these compounds is described and the use of the combination of one of these compounds with an anticancer agent such as decarbazine, doxorubicin, daunorubicin, cyclophosphamide, busulfex, busulfan, vinblastine, vincristine, bleomycin, etoposide, topotecan, irinotecan, taxotere, taxol, 5-fluorouracil, methotrexate, gemcitabine, cisplatin, carboplatin and chlorambucil.式I，式I.1，式I.2，式IA，式IB，式IC和式II的苯基酮羧酸鹽化合物與取代的芳族化合物以及它們的藥學上可接受的鹽在用於治療癌症中的用途。描述了這些化合物中的兩種聯合的用途、以及這些化合物中的一種和下列抗癌劑聯合的用途，所述抗癌劑例如氨烯咪胺，阿黴素，柔紅黴素，環磷醯胺，白舒非，白消安，長春鹼，長春新鹼，博萊黴素，鬼臼亞乙苷，托泊替康，依立替康，泰索帝，紫杉醇，5-氟尿嘧啶，甲氨蝶呤，吉西他濱，順鉑，卡鉑和苯丁酸氮芥。