Daniel Lawrence;Manuel Yepes;Ulf Eriksson;Linda Fredriksson;Enming Joe Su;Dudley Strickland
发明人:
Ulf Eriksson,Daniel Lawrence,Enming Joe Su,Dudley Strickland,Manuel Yepes,Linda Fredriksson
申请号：
US11736499
公开号：
US08147828B2
申请日:
2007.04.17
申请国别(地区):
US
年份:
2012
代理人:
摘要：
Methods and compositions for modulating blood-neural barrier (BNB) for the treatment of CNS conditions such as edema, and for increased drug delivery efficacy across the BNB. The present invention further relates to improved tPA treatment of ischemic cerebrovascular and related diseases in combination with antagonism of the PDGF signaling pathway. The inventive method and composition is particularly suitable for conjunctive therapy of ischemic stroke using tPA and an anti-PDGF-C antagonist or an anti-PDGFR-α antagonist.
