A targeting guide device is configured to support a biopsy device. The guide device comprises a first plate and a second plate. A biopsy device may be supported by either the first plate or the second plate. The targeting guide device is also configured to be secured to a compression grid plate, which is situated adjacent the tissue to be biopsied. The compression grid plate includes apertures that are defined by grid walls. Either or both of the first plate and the second plate have a slot within which a grid wall may be positioned so as to secure placement of the targeting guide device. In addition, either or both of the first plate and the second plate have an access hole through which a biopsy device may be inserted. A flanged insert may be positioned through the access hole to provide further support for the biopsy device.
