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INTERLEUKIN-2/INTERLEUKIN-2 RECEPTOR ALPHA FUSION PROTEINS AND METHODS OF USE
专利权人:
UNIVERSITY OF MIAMI
发明人:
MALEK, Thomas
申请号:
AU2020203352
公开号:
AU2020203352A1
申请日:
2020.05.22
申请国别(地区):
AU
年份:
2020
代理人:
摘要:
#$%^&*AU2020203352A120200702.pdf#####Various methods and compositions are provided which can be employed to modulate the immune system. Compositions include a fusion protein comprising: (a) a first polypeptide comprising Interleukin-2 (IL-2) or a functional variant or fragment thereof; and (b) a second polypeptide, fused in frame to the first polypeptide, wherein the second polypeptide comprises an extracellular domain of Interleukin-2 Receptor alpha (IL-2Ra ) or a functional variant or fragment thereof, and wherein the fusion protein has IL-2 activity. Various methods are provided for modulating the immune response in a subject comprising administering to a subject in need thereof a therapeutically effective amount of the IL-2/IL-2Ra fusion protein disclosed herein.
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来源网址:
http://www.ckcest.cn/home/
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