PREPARATIONS EN SOLUTION CONTENANT DES ANTICORPS STABILISES A L'AIDE DE SUCRE

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专利权人:

CHUGAI SEIYAKU KABUSHIKI KAISHA

发明人:

KAKUTA, MASAYA,KIKUCHI, JUN,MIZUSHIMA, HIDEFUMI,IMAEDA, YOSHIMI

申请号：

CA2474943

公开号：

CA2474943C

申请日:

2003.02.14

申请国别(地区):

CA

年份:

2016

代理人:

摘要：

Disclosed herein is an antibody-containing solutionformulation comprising a sugar and a surfactant asstabilizers. The sugar is sucrose or trehalose, whereasthe surfactant is Polysorbate 80 or 20. The antibody tobe stabilized with the solution formulation is ahumanized anti-interleukin-6 receptor antibody hPM-1 orthe anti-HM1.24 antibody. The solution formulationprevents antibody multimer molecule formation induced bylight.

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