MORICONI, ALESSIO,ALLEGRETTI, MARCELLO,BERTINI, RICCARDO,CESTA, MARIA CANDIDA,BIZZARRI, CINZIA,COLOTTA, FRANCESCO
申请号：
CA2511582
公开号：
CA2511582C
申请日:
2004.02.04
申请国别(地区):
CA
年份:
2012
代理人:
摘要：
Selected 2-arylacetic acids, their derivatives and pharmaceutical compositionsthat contain these compounds are useful in inhibiting chemotactic activationof neutrophils (PMN leukocytes) induced by the interaction of Interleukin-8(IL-8) with CXCR1 and CXCR2 membrane receptors. The compounds are used for theprevention and treatment of pathologies deriving from said activation. Inparticular, 2(ortho)-substituted arylacetic acids or their derivatives, suchas amides and sulfonamides, lack cyclo-oxygenase inhibition activity and areparticularly useful in the treatment of neutrophil-dependent pathologies suchas psoriasis, ulcerative colitis, melanoma, chronic obstructive pulmonarydisease (COPD), bullous pemphigoid, rheumatoid arthritis, idiopathic fibrosis,glomerulonephritis and in the prevention and treatment of damages caused byischemia and reperfusion.
