Haoxi HUANG,Guoqing ZHUO,Guoning SHANG,Zhen LIANG,Ting CHU,Cuicui CHEN,Ming LUO,Yingfu LI,Zhonghai SU
申请号：
US16467866
公开号：
US20190308981A1
申请日:
2016.12.13
申请国别(地区):
US
年份:
2019
代理人:
摘要：
The present invention provides a hydrobromide of methyl 3-[(4s)-8-bromo-1-methyl-6-(2-pyridyl)-4H-imidazol[1,2-a][1,4]benzodiazepine-4-yl] propionate and its related crystal forms, preparation method and use thereof. The hydrobromide has excellent solubility (>；100 mg/ml), which is significantly superior to other currently commercially available or developed salt products, and is especially suitable for the preparation of injections, has relatively good stability in various crystal forms, and has good practical value and market prospects.
