ENCASED TAMPER RESISTANT CONTROLLED RELEASE DOSAGE FORMS

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专利权人:

PURDUE PHARMA L.P.

发明人:

HUANG, HAIYONG, HUGH

申请号：

MYPI 2013002298

公开号：

MY166034A

申请日:

2011.12.21

申请国别(地区):

MY

年份:

2018

代理人:

摘要：

IN CERTAIN EMBODIMENTS, THE PRESENT INVENTION IS DIRECTED TO A SOLID CONTROLLED RELEASE DOSAGE FORM COMPRISING: A CORE COMPRISING A FIRST PORTION OF AN OPIOID ANALGESIC DISPERSED IN A FIRST MATRIX MATERIAL； AND A SHELL ENCASING THE CORE AND COMPRISING A SECOND PORTION OF THE OPIOID ANALGESIC DISPERSED IN A SECOND MATRIX MATERIAL； WHEREIN THE AMOUNT OF OPIOID ANALGESIC RELEASED FROM THE DOSAGE FORM IS PROPORTIONAL WITHIN 20% TO ELAPSED TIME FROM 8 TO 24 HOURS, AS MEASURED BY AN IN VITRO DISSOLUTION IN A USP APPARATUS 1 (BASKET) AT 100 RPM IN 900 ML SIMULATED GASTRIC FLUID WITHOUT ENZYMES (SGF) AT 37 C.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/