John A. McCauley,Hemaka A. Rajapakse,Thomas J. Greshock,John Sanders,Boyoung Kim,Vanessa L. Rada,Jonathan T. Kern,Heather H. Stevenson,Mark T. Bilodeau
申请号：
US13880992
公开号：
US09233977B2
申请日:
2011.10.25
申请国别(地区):
US
年份:
2016
代理人:
摘要：
Disclosed are compounds of Formula (I): and the pharmaceutically acceptable salts thereof, wherein “A” is S— —SO—, —SO2—, —O— or NRac—, wherein Rac is H, or C1-20 alkyl and R1 through R5 are defined herein. Also disclosed are pharmaceutical formulations comprising a compound of Formula I and methods of treating, managing, or ameliorating diseases amenable to treatment, management, or amelioration by inhibition of LRRK2 kinase activity, for example, Parkinsons disease.
