BUCKMAN, Brad Owen,NICHOLAS, John Beamond,YUAN, Shendong,ADLER, Marc,EMAYAN, Kumaraswamy,MA, Jingyuang
申请号：
PE2019000732
公开号：
PE20191153A1
申请日:
2017.09.27
申请国别(地区):
PE
年份:
2019
代理人:
摘要：
Referred to a compound having the selected structure of the formulas (Ia, Ib, Ic, Id, Ie, If, Ig, Ih, Im, In) or one of its pharmaceutically acceptable salts, where: A2 is optionally substituted heterocyclyl of 3-10 members, optionally substituted C6-10 aryl, among others； A4 is optionally substituted C6-10 aryl, optionally 5-10 membered heteroaryl, among others； A3 is optionally substituted C6-10 aryl, optionally substituted 5-10 membered heteroaryl, among others； A5 is 3-10 membered optionally substituted heterocyclyl, optionally substituted C6-10 aryl, among others； A6 is optionally substituted C6-10 aryl,Among other things, 5-10 members are substitutes for heterosexuals； A7 is substitutes for C6-10, and 5-10 members are substitutes for heterosexuals. R1 is h, COOH, ch2no2, among others； R6 is h or C1-4 alternative tar； a, B, D, X and Z are independently selected from C (R4) and N； R4 is h, C1-4 tar, etc.； and NR5, O, s or SO2. These non large alpha HCH compounds are small molecules of calpaina modulators for the treatment of fibrotic diseases or secondary States, rheumatoid arthritis,There are others It also refers to the pharmaceutical preparation methods and compositions including these compounds.Referido a un compuesto que tiene la estructura seleccionada de las formulas (I-a, I-b, I-c, I-d, I-e, I-f, I-g, I-h, I-m, I-n) o una de sus sales farmaceuticamente aceptables, en donde: A2 es heterociclilo opcionalmente sustituido de 3-10 miembros, arilo C6-10 opcionalmente sustituido, entre otros； A4 es arilo C6-10 opcionalmente sustituido, heteroarilo opcionalmente sustituido con 5-10 miembros, entre otros； A3 es arilo C6-10 opcionalmente sustituido, heteroarilo opcionalmente sustituido de 5-10 miembros, entre otros； A5 es heterociclilo opcionalmente sustituido de 3-10 miembros, arilo C6-10 opcionalmente sustituido, entre otros； A6 es arilo C6-10 opcionalmente sustituido, heteroarilo opcionalmente sustituido de 5-10 miembros, entre otros； A7 es arilo C6-10 opcional
